PREDICT-COVID

PREDICT-COVID (Prognostication of Recovery in Early DIsorders of Consciousness afTer COVID-19) is a study of patients who survive the critical illness of COVID-19 but thereafter suffer a prolonged disorder of consciousness. By acquiring structural MRI, functional MRI, and neurophysiology, PREDICT-COVID seeks to predict the recovery of consciousness and long term neurologic function in these patients.

Selected Publications

Fischer D, Edlow BL. Coma prognostication after acute brain injury: A review. JAMA Neurology. 2024; doi: 10.1001/jamaneurol.2023.5634. PMCID pending. [PubMed] [Altmetric] [JAMA Neurology Twitter]

Waldrop G*, Safavynia SA*, Barra ME*, Agarwal S, Berlin DA, Boehme AK, Brodie D, Choi JM, Doyle K, Fins JJ, Ganglberger W, Hoffman K, Mittel AM, Roh D, Mukerji SS, Der Nigoghossian C, Park S, Schenck EJ, Salazar-Schicchi J, Shen Q, Sholle E, Velazquez AG, Walline MC, Westover MB, Brown EN, Victor J, Edlow BL**, Schiff ND**, Claassen J**. Prolonged unconsciousness is common in COVID-19 and associated with hypoxemia. Annals of Neurology. 2022;91:740-755. (*co-first; **co-last) PMCID PMC9082460. [PubMed] [Altmetric] [Press Release] [Boston Globe]

Fischer D, Snider SB, Barra ME, Sanders WR, Rapalino O, Schaefer P, Foulkes AS, Bodien YG, Edlow BL. Disorders of consciousness associated with COVID-19: A prospective, multimodal study of recovery and brain connectivity. Neurology. 2021; DOI 10.1212/WNL.0000000000013067. PMCID pending. [PubMed] [Altmetric]

Edlow BL, Boly M, Chou SHY, Fischer D, Kondziella D, Li LM, Mac Donald CL, McNett M, Newcombe VFJ, Stevens RD, Menon DK and GCS-NeuroCOVID. Common data elements for COVID-19 neuroimaging: A GCS-NeuroCOVID proposal. Neurocritical Care. 2021;34:365-370. PMCID PMC7878171. [PubMed] [CDEs on Zenodo]

Fischer D, Edlow BL. Long-term recovery from disordered consciousness associated with COVID-19. Neurocritical Care. 2021;35:916-918. PMCID PMC8510570. [PubMed] [Altmetric]

Conklin J, Frosch MP, Mukerji SS, Rapalino O, Maher MD, Schaefer PW, Lev MH, Gonzalez RG, Das S, Champion SN, Magdamo C, Sen P, Harrold GK, Alabsi H, Normandin E, Shaw B, Lemieux JE, Sabeti PC, Branda JA, Brown EN, Westover MB, Huang SY*, Edlow BL*. Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19. Journal of the Neurological Sciences. 2021;421:117308. (*co-senior authors) PMCID PMC7832284. [PubMed] [PlumX]

Edlow BL. Early rehabilitation for patients with disorders of consciousness after severe COVID-19. Neurocritical Care. 2021; https://doi.org/10.1007/s12028-021-01361-7. PMCID PMC8494457. [Pubmed] [Altmetric]

Fischer D, Threlkeld ZD, Bodien YG, Kirsch JE, Huang SY, Schaefer PW, Rapalino O, Hochberg LR, Rosen BR, Edlow BL. Intact brain network function in an unresponsive patient with COVID-19. Annals of Neurology. 2020;88:851-854. PMCID PMC7361474 [PubMed] [Altmetric] [GitHub]

Edlow BL, Claassen J, Victor JD, Brown EN, Schiff ND. Delayed reemergence of consciousness in survivors of severe COVID-19. Neurocritical Care. 2020;33:627-629. PMCID PMC7654564 [PubMed] [Altmetric]