ReBlast

 

The Long-term Effects of Repeated Blast Exposure on United States Special Operations Forces (ReBlast) study aims to develop a diagnostic test to detect brain injury associated with repeated blast exposure.  The ReBlast Pilot study was conducted from 2021-2023 (ClinicalTrials.gov). The ReBlast Precision study was launched in 2025 and is ongoing (ClinicalTrials.gov).

 
 

The above figure shows the multimodal neuroimaging protocol used to identify the effects of repeated blast exposure on the brains of active-duty United States Special Operations Forces personnel in the ReBlast study.  Figure reproduced from Edlow et al. Journal of Neurotrauma, 2022

 

Selected ReBlast Publications

 

Gilmore N*, Tseng CJ*, Maffei C*, Tromly SL, Deary KB, McKinney IR, Kelemen JN, Healy BC, Hu CG, Ramos Llorden G, Masood M, Cali RJ, Guo J, Belanger HG, Yao EF, Baxter T, Fischl B, Foulkes AS, Polimeni JR, Rosen BR, Perl DP, Hooker JM, Zürcher NR, Huang SY, Kimberly WT, Greve DN, Mac Donald CL, Dams-O’Connor K, Bodien YG**, Edlow BL**.  Impact of repeated blast exposure on active-duty United States Special Operations Forces. Proceedings of the National Academy of Sciences of the U.S.A. 2024;121:e2313568121.(*co-first; ** co-last) [PubMed] [Altmetric] [Press Release]

Edlow BLGilmore NM, Tromly SL, Deary KB, McKinney IR, Hu CG, Kelemen JNMaffei C, Tseng CJ, Ramos Llorden G, Healy BC, Masood MCali RJ, Baxter T, Yao EF, Belanger HG, Benjamini D, Basser PJ, Priemer DS, Kimberly WT, Polimeni JR, Rosen BR, Fischl B, Zürcher NR, Greve DN, Hooker JM, Huang SY, Caruso A, Smith GA, Szymanski TG, Perl DP, Dams-O’Connor K, Mac Donald CL, Bodien YG. Optimizing Brain Health of United States Special Operations Forces. Journal of Special Operations Medicine. 2023;23:47-56. [PubMed] [JSOM Podcast]

Edlow BL*, Bodien YG*, Baxter T, Belanger HG, Cali RJ, Deary KB, Fischl B, Foulkes AS, Gilmore N, Greve DN, Hooker JM, Huang SY, Kelemen JN, Kimberly WT, Maffei CMasood M, Perl DP, Polimeni JR, Rosen BR, Tromly SL, Tseng CJ, Yao EF, Zürcher NR, Mac Donald CL**, Dams-O’Connor K**. Long-term effects of repeated blast exposure in United States Special Operations Forces personnel: A pilot study protocol. Journal of Neurotrauma. 2022;39:1391-1407. (*co-first, **co-last) PMCID PMC9529318. [PubMed]