The NICC Lab developed the Connectome-Based Clinical Trial Platform (CCTP), a novel paradigm for developing targeted therapies that promote early recovery of consciousness in patients with acute severe traumatic brain injury.  We are now implementing and testing the CCTP in a clinical trial of intravenous methylphenidate called STIMPACT: Stimulant Therapy Targeted to Individualized Connectivity Maps to Promote ReACTivation of Consciousness.

A new treatment that promotes early recovery of consciousness in the intensive care unit (ICU) would benefit patients and families by reducing the likelihood of premature withdrawal of life-sustaining therapy, facilitating self- expression, enabling autonomous decision-making, decreasing ICU complications related to immobility, and increasing access to post-ICU rehabilitative care.

Monti MM, Spivak NM, Edlow BL, Bodien YG. What is a minimal clinically important difference for clinical trials in patients with Disorders of Consciousness? A novel probabilistic approach. PLOS ONE. 2023;18:e0290290. PMCID PMC10449161. [PubMed]

Edlow BL, Barra ME, Zhou DW, Foulkes AS, Snider SB, Threlkeld ZD, Chakravarty S, Kirsch JE, Chan ST, Meisler SL, Bleck TP, Fins JJ, Giacino JT, Hochberg LR, Solt K, Brown EN, Bodien YG. Personalized connectome mapping to guide targeted therapy and promote recovery of consciousness in the intensive care unit. Neurocritical Care. 2020;33:364-375. PMCID PMC8336723. [PubMed] [Editorial] [Altmetric]

Barra ME, Izzy S, Sarro-Schwartz, A, Hirschberg RE, Mazwi N, Edlow BL. Stimulant therapy in acute traumatic brain injury: Prescribing patterns and adverse event rates at two Level 1 trauma centers. Journal of Intensive Care Medicine. 2019; doi: 10.1177/0885066619841603. [Epub ahead of print]. PMCID pending. [PubMed] [Altmetric]

Pais-Roldan P, Edlow BL, Jiang Y, Stelzer J, Zou M, Yu X.  Multimodal assessment of recovery from coma in a rat model of diffuse brainstem tegmentum injury. NeuroImage. 2019;189:615-630. PMCID pending. [PubMed] [PlumX]